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LONDON (Thomson Financial) - GlaxoSmithKline PLC reported positive final results from a phase II trial of its experimental cancer vaccine MAGE-A3, in patients with non-small cell lung cancer.The company said it now plans to start a phase III efficacy and safety trial, recruiting 2,270 patients, which it claims will be the largest clinical trial ever conducted in lung cancer treatment.Final analysis of the phase II trial showed a 27 pct reduction in relative risk of cancer recurrence following surgery, in patients treated with the ther ...

ALIMTA (pemetrexed for injection) showed additional utility in the treatment of the most diagnosed type of cancer , according to data presented at the 43rd Annual Meeting of the American Society of Clinical Oncology (ASCO). Results from a Phase III study suggest that a first-line ALIMTA-based regimen may deliver less toxicity than a commonly used therapy in advanced non-small cell lung cancer (NSCLC). ALIMTA is manufactured and marketed by Eli Lilly and Company.A prospective, randomized, multicenter Phase III study was conducted to co ...

Go smokeless and make it stickFROM STAFF AND NEWS SERVICE REPORTSTuesday, June 5, 2007Addiction counselor and clinician Gregg Benson often hears that becoming clean and sober is easier than attempting to quit smoking.Like any other addict, smokers develop a full-fledged relationship with their habit and while breaking up is hard to do, quitting may be downright torture. Severing ties to cigarettes also means saying goodbye to the entire smoking experience, said Benson, a Morristown-based consultant and trainer who specializes in addic ...

The science has long been clear that smoking causes cancer, but new research shows that children could inherit genetic damage from a father who smokes.Canadian researchers have demonstrated in mice that smoking can cause changes in the DNA sequence of sperm cells, alterations that could potentially be inherited by offspring. The results of their study are published in the June 1 issue of Cancer Research, a journal of the American Association for Cancer Research."Here we are looking at male germline mutations, which are mutations in th ...

Alex A. Adjei, MD, PhD, Senior Vice President of Clinical Research and Chair of the Department of Medicine at Roswell Park Cancer Institute (RPCI) will present clinical trial results of a "Window of Opportunity" phase II study of Sorafenib in patients with advanced lung cancer, at the 2007 annual meeting of the American Society of Clinical Oncology (ASCO), June 1 - 5, in Chicago, IL.Sorafenib, a molecularly targeted oral medication that attacks tumor cells and tumor vasculature, was evaluated as a single agent in patients with previou ...

In less than a month, England's millions of smokers will no longer be able to light up in bars, restaurants and offices - a ban pioneered by Wales and Scotland.In anticipation of the new law - which bans smoking in enclosed public spaces and workplaces from July 1 - many will try to quit. But it won't be easy. Going cold turkey is the least effective approach with only a 3 per cent chance. You're more likely to give up with nicotine replacement therapy, prescription drugs, counselling and support.As Ruth Bosworth, from charity QUIT, e ...

Washington - U.S. researchers found that the estrogen in women may have an effect on chemotherapy, which is why older women with lung cancer have a much longer life span than men of the same age.Kathy Albain of the Cardinal Bernardin Cancer Center at Loyola University in Maywood, Illinois, was amazed at how her older woman patients are able to do much better, whereby they are able to live a median of 11 months, which is much better compared to the men's eight months.Albain said in a telephone interview that the higher estrogen levels ...

IDM Pharma, Inc. (Nasdaq: IDMI) today announced that interim data from the Phase II study of EP-2101 showed the vaccine was well tolerated and suggested a survival benefit in patients with non-small cell lung cancer (NSCLC) who were vaccinated with EP-2101 compared to concurrent non-vaccinated patients. In addition, generation of a robust immune response was also demonstrated. The data were presented at the 2007 American Society of Clinical Oncology (ASCO) 43rd annual meeting in Chicago."We are encouraged by the favorable trend that s ...

Agennix Incorporated today announced results from a fourth positive Phase II trial with its lead molecule talactoferrin alfa, an immunomodulatory protein with a novel mechanism of action. This trial, which compared oral talactoferrin monotherapy to placebo in patients with refractory non-small cell lung cancer (NSCLC), met its primary endpoint of a statistically significant improvement in overall survival. Secondary efficacy endpoints also showed improvement consistent with the primary endpoint results. Oral talactoferrin was well tol ...

European researchers have reported for the first time that radiation therapy to the head ("prophylactic cranial irradiation," or PCI) given to patients who respond to chemotherapy for advanced small cell lung cancer cuts the risk that the cancer will spread to the brain by about two-thirds, and as a result extends patients' lives.The findings were presented here Monday at the annual meeting of the American Society of Clinical Oncology."Our data suggests that all patients with extensive small cell lung cancer who respond to chemotherap ...

By JEFF MEYERSStaff WriterParents want to do what is best for their children, but sometimes that is a lot easier said than done.One of the most important steps an expectant mom can take to ensure her baby will have a good start in life is not to smoke or to quit smoking if she does.Although a majority of women recognize that need, the insidious habit does have powers over some that make the step a lot more difficult to succeed at.Several dozen health-care providers from the region participated in a recent discussion on smoking and pre ...

Science Daily - Women with advanced lung cancer survive longer than men if they are age 60 or older, but researchers no found difference by sex among people younger than 60, a finding that may point the way to improved treatment, according to a study released at the American Society of Clinical Oncology (ASCO) annual meeting."If estrogen levels interact with the efficacy of certain chemotherapy drugs or some other, as-yet-undefined factor, we can utilize this knowledge to design new therapies," said lead study author Dr. Kathy S. Alba ...

By Megan RauscherMon Jun 4, 6:20 PM ETPreventive radiation to the brain significantly reduces the risk of lung cancer spreading to this organ and improves survival, according to data presented in a session Monday at the 43rd annual meeting of the American Society of Clinical Oncology.All of the patients studied had advanced small-cell lung cancer, a type that carries a poor prognosis and is generally not amenable to surgical removal."Brain metastases are a common problem in small-cell lung cancer," study coordinator Dr. Ben Slotman, p ...

SATURDAY, June 2 (HealthDay News) -- U.S. researchers say they've developed new tests that can determine the precise genetic pathways that lead to lung cancer.Being able to examine these genomic "signatures" may provide patients with alternatives to chemotherapy. For example, patients may be able to be treated with drugs that target the specific faulty pathway that caused their cancer, the researchers said."Traditional chemotherapy is not always effective. Even when we are able to match the right chemotherapy with the right patient, 7 ...

ANN ARBOR, Mich., June 4 (UPI) -- A U.S. study has determined why lung cancer drugs work better in Japanese patients than they do in U.S. lung cancer patients.A groundbreaking 2006 international study found a group of Japanese patients with advanced non-small cell lung cancer survived longer -- and had a higher rate of side effects -- than U.S. patients with the same diagnosis, when both groups were given two well-known drugs for the disease.Now, a U.S. follow-up study suggests the reasons appear to lie in subtle variations in certain ...

Radiation may help patients with small-cell lung cancer live longer by preventing their tumors from spreading to the brain, according to a study that experts predict will create a new standard of care. Small-cell tumors account for about 30,000 to 40,000 of the 213,380 annual cases of lung cancer.The study, to be presented today at the oncology conference, involved patients with extensive small-cell cancers, which already have spread around the lungs or to other organs. If cancer reaches the brain, the effects can be devastating, caus ...

By Mary Beth Schneidermary.beth.schneider@indystar.comJune 3, 2007Delana Bennington's phone has been ringing a lot lately, thanks to the state legislature.Bennington is coordinator of Tobacco Free Boone County, one of 100 groups in 87 counties that receives funding and assistance from Indiana Tobacco Prevention and Cessation.She attributed the increased interest to a cigarette tax increase of 44 cents per pack that will take effect next month and higher gasoline prices."I'm receiving so many phone calls from people ready to quit. They ...

his issue with a vengeance.This producer is the self-proclaimed ambassador for the 'Quit Smoking' campaign in Mumbai. Let's say he's at least the filmi industry's emissary to start with.Ever since he started shooting for his film No Smoking , Kumar Mangat has taken up this issue with a vengeance. We told you about how he planned the 'pay a fine' system for anyone who was caught smoking on the sets of the film. The kitty got bigger and heavier by the day, and no one complained because all the money went to charity.Smoking for a cause, ...

The UK's National Institute for Health and Clinical Excellence, or NICE, has recommended Pfizer's Champix for use on the NHS for adult smokers looking to quit.In its final appraisal determination, NICE concluded that Champix (varenicline) was "superior to NRT (nicotine replacement therapy) and bupropion in achieving continuous abstinence" and that its use in smoking cessation was "likely to be a cost-effective use of National Health Service resources."Champix, the first new prescription aid to smoking cessation treatment in nearly a d ...